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Research ArticleArticles
Open Access

Lifetime Trajectories and Drivers of Socioeconomic Health Disparities

Evidence from Longitudinal Biomarkers in the Netherlands

View ORCID ProfileAilun Shui, View ORCID ProfileGerard J. van den Berg, View ORCID ProfileJochen O. Mierau and View ORCID ProfileLaura Viluma
Journal of Human Resources, June 2026, 61 (Supplement) S98-S130; DOI: https://doi.org/10.3368/jhr.0225-14125R2
Ailun Shui
Ailun Shui is a doctoral student at the University of Groningen .
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  • For correspondence: a.shui{at}rug.nl
Gerard J. van den Berg
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Jochen O. Mierau
Jochen O. Mierau is a Professor of Public Health Economics at the University Medical Center Groningen and the University of Groningen.
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Laura Viluma
Laura Viluma is an Assistant Professor of Health Economics at the University of Groningen.
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  • Stacked percent graph showing the share of individuals with different biomarker-related risk counts from age 18 to 80.
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    Figure 1

    Evolution of Biomarker-Related Risks over the Life Cycle

    Notes: This figure illustrates the share of observations with varying numbers of biomarker-related risks across ages using pooled observations from an unbalanced panel data set. The sample covers ages 18–80. The number of biomarker-related risks refers to the count of biomarkers exceeding the clinical threshold (Table 1) for an individual at a given age. The different colors (gray shades in black and white version) represent different numbers of risks, with the lowest risk at bottom and highest risk at the top. The proportion of the color/shade at each age is the share of observations at this age.

  • Stacked percent graph showing the share of individuals with different chronic disease counts from age 18 to 80.
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    Figure 2

    Evolution of Aging-Related Chronic Diseases over the Life Cycle

    Notes: This figure illustrates the share of observations with varying numbers of aging-related chronic diseases across ages using pooled observations from an unbalanced panel data set. The sample covers ages 18–80. The number of chronic diseases refers to the count of conditions an individual currently has or has previously had at a given age. Details on the list of chronic diseases are provided in Table 2. Different colors (gray shades in black and white version) represent different numbers of chronic diseases, with the lowest at the bottom and the highest at the top. The proportion of the color/shade at each age is the share of observations at this age.

  • Line graph showing trajectories of the scaled allostatic load index, the scaled chronic disease index, and the three-year mortality rate across age.
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    Figure 3

    Life Cycle Profile of ALI, CDI, and Three-Year Mortality

    Notes: This figure presents the trajectories of ALI, CDI, and three-year mortality rate over the life cycle using pooled observations from an unbalanced panel data set. The sample covers ages 18–80. Due to limitations in death record availability, the number of observations for three-year mortality rate is smaller than for ALI and CDI (see Section III.C for details). For CDI, the figure (and subsequent figures that stratify by gender and education) follows the corresponding figures in Danesh et al. (2024). In our setting, to ensure comparability between CDI and ALI, we rescale the two indexes using a min–max scaling approach. We apply the lpoly smoothing method, a kernel-weighted local polynomial regression, to smooth the trajectories of ALI, CDI, and three-year mortality. Specifically, we use the Epanechnikov kernel with a zero-degree polynomial, which minimizes noise while preserving the underlying data pattern. The 95 percent confidence intervals are shown. The larger variation at younger and older ages reflects the smaller sample sizes in these groups.

  • Line graph showing educational differences in the allostatic load index for males and females from age 18 to 80.
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    Figure 4

    Educational Disparities in the ALI by Age and Gender

    Notes: This figure presents the trajectories of educational disparities in ALI by age and gender using pooled observations from an unbalanced panel data set. The sample covers ages 18–80. High education is defined as higher vocational or university education according to the Dutch education system, while the rest of the sample is classified as low education (see Section II.B for details). We apply the lpoly smoothing method, a kernel-weighted local polynomial regression of y on x, using the Epanechnikov kernel function with a zero-degree polynomial. The 95 percent confidence intervals are shown. Larger variation at younger and older ages reflects smaller sample sizes in these groups.

  • Line graph showing educational differences in the allostatic load index by birth cohort from age 18 to 80.
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    Figure 5

    Educational Disparities in ALI Across Age and Birth Cohorts

    Notes: This figure examines the importance of cohort effects by grouping individuals into ten-year birth cohorts and presenting educational disparities in ALI across ages using pooled observations from an unbalanced panel data set. For example, “80s” refers to participants born in the 1980s. However, the figure still reflects a mix of cohort and age effects because individuals are not followed continuously over time. We apply the lpoly smoothing method, a kernel-weighted local polynomial regression of y on x, using the Epanechnikov kernel function with a zero-degree polynomial. Large variation is observed for the 30s and 90s cohorts due to smaller sample size.

  • Dot plot showing the prevalence of high-risk biomarkers for young adults by gender and educational attainment.
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    Figure 6

    Educational Disparities in the Prevalence of High-Risk Biomarkers Among Individuals Aged Under 30

    Notes: This figure illustrates differences in the prevalence of each biomarker-related risk across education groups, segmented by gender. Observations from all three waves are pooled for this analysis. For example, a value of 0.027 for females’ heart rate indicates that 2.7 percent of females have a heart rate above 90 beats per minute (see Table 1 for clinical thresholds for other biomarkers). Among females, the differences in total cholesterol, HbA1c, glucose, and diastolic blood pressure between low- and high-education groups are statistically insignificant at the 10 percent level. Among males, the differences in heart rate and diastolic blood pressure are statistically insignificant at the 10 percent level. All other differences are significant at the 10 percent level.

  • Stacked bar graph showing the contributions of different factors to the allostatic load index by gender and age group.
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    Figure 7

    R-Squared Contribution of Modifiable Factors to ALI by Gender and Age Groups

    Notes: This figure presents the Shapley–Owen decomposition results of the relative importance of modifiable factors for ALI by age group. For each age group, we run a linear regression of ALI on education, neighborhood SES, employment, a set of modifiable factors, and basic demographics. The stacked bars display the contribution of each factor to the overall R-squared of the models. Details on these modifiable variables are provided in Section II.B.

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    Table 1

    Definitions and Clinical Cutoff Points of Biomarkers Used to Construct the ALI

    SystemBiomarkerDescriptionThreshold
    Cardiovascular systemSystolic blood pressure (mm Hg)The maximum pressure in arteries during the active phase of the heartbeat≥140
    Diastolic blood pressure (mm Hg)The heart refills with blood and the pressure in the arteries is at its lowest≥90
    Heart rate (per minute)The number of times the heart beats in one minute (electrocardiogram)≥90
    Metabolic systemBody mass index (BMI)5A simple calculation used to assess whether a person has a healthy body weight for their height≥30
    Waist-to-hip ratio (WHR)A measurement used to assess body fat distribution≥0.90 for males; ≥0.85 for females
    Total cholesterol (mmol/L)The sum of different types of cholesterol in the blood≥6.2
    High-density lipoprotein (HDL) cholesterol (mmol/L)“Good” cholesterol that helps clear other forms of cholesterol≤1
    Low-density lipoprotein (LDL) cholesterol (mmol/L)“Bad” cholesterol that high levels can lead to the buildup of cholesterol in the arteries≥4.1
    Glycosylated hemoglobin (HbA1c)(mmol/mol)A blood test that measures the average level of blood sugar (glucose) over the past 2–3 months≥48
    Glucose (mmol/mol)A simple sugar and a primary energy source for the body’s cells≥7
    Triglycerides6 (mmol/L)A type of fat (lipid) found in blood≥1.7
    Kidney functionCreatinine (mmol/L)Creatinine is a waste product that forms when muscles break down creatine, a substance found in the muscles and consumed through meat and fish≥90
    • Notes: For HbA1c, the variable measured in mmol/L contains 23,000 missing values in wave 1a, whereas the variable measured in percentages has only 764 missing values. To address this issue, we use the alternative variable for HbA1c and convert its unit accordingly. Consequently, there is a small transformation error in this variable due to rounding. BMI is calculated as BMI = Weight (kg)/Height (m)2. WHR is calculated as WHR = Waist circumference (cm)/Hip circumference (cm).

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    Table 2

    Categories of Aging-Related Chronic Diseases Used to Construct the CDI

    CategorySpecific Disorder
    Cancer
    Cardiovascular diseasesHeart attack, heart failure, stroke
    Diabetes
    Digestive system diseasesUlcerative colitis, gallstones, hepatitis
    Chronic fatigue syndrome
    Kidney and bladder diseasesKidney stones, renal failure
    Musculoskeletal conditionsArthritis, fibromyalgia, osteoarthritis, osteoporosis, repetitive strain injury
    Neurological disordersDementia, Parkinson’s disease
    Respiratory diseasesEmphysema or chronic bronchitis
    • Notes: This table presents the 19 aging-related chronic diseases in Lifelines, based on self-reported information. These diseases are included according to the chronic disease questionnaire and the data availability in Lifelines. Cancer includes all types of cancers, and diabetes refers to both type 1 and type 2 diabetes.

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    Table 3

    Sample Selection Process for the Analytical Sample

    Selected InSelected Out: Missing Value in 12 BiomarkersSelected Out: Not FastingSelected Out: Missing Value in 19 Chronic DiseasesSelected Out: Missing in Demographics (Including Education)Selected Sample
    Wave 1a150,6058,6762,2263,1488,885127,047
    Wave 2a99,6087,5352,12103,10886,513
    Wave 3a60,7945,0041,617090153,272
    Observations311,00721,2156,9183,14812,894266,832
    • Notes: This table presents the sample selection process of our analysis. We include participants with no missing health information in the key variables. Fasting indicates that the biosample was collected after fasting, ensuring the accuracy of blood samples and measurements. For details regarding attrition, see Section II.C.

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    Table 4

    Sample Summary Statistics

    Wave
    Wave 1aWave 2aWave 3aTotal
    Observations127,04786,51353,272266,832
    (47.6%)(32.4%)(20.0%)(100%)
    Panel A: Demographics
    Age45.30350.14755.88748.987
    (11.839)(12.013)(11.158)(12.441)
    Gender (Male = 1)0.4210.4160.4150.418
    (0.494)(0.493)(0.493)(0.493)
    Panel B: Education
    Low87,29657,49332,108176,897
    (68.7%)(66.5%)(60.3%)(66.3%)
    High39,75129,02021,16489,935
    (31.3%)(33.5%)(39.7%)(33.7%)
    Panel C: Biomarkers
    Systolic blood pressure125.565128.724131.968127.867
    (15.213)(16.324)(15.983)(15.928)
    Diastolic blood pressure73.99974.20982.43575.751
    (9.333)(9.472)(10.995)(10.288)
    Heart rate (ECG)67.31166.88765.00166.712
    (11.199)(11.192)(10.525)(11.100)
    Body mass index (BMI)26.13526.13726.84126.276
    (4.285)(4.273)(4.473)(4.329)
    Waist-to-hip ratio (WHR)0.9070.9030.9310.911
    (0.084)(0.089)(4.602)(2.058)
    Total cholesterol5.0985.0975.1945.117
    (0.999)(0.984)(1.008)(0.997)
    High-density lipoprotein cholesterol1.4911.5181.5151.504
    (0.397)(0.423)(0.421)(0.411)
    Low-density lipoprotein cholesterol3.2483.3283.3343.291
    (0.913)(0.912)(0.906)(0.912)
    Glucose5.0165.0745.3665.105
    (0.822)(0.885)(0.972)(0.884)
    Hemoglobin A1C37.24336.72638.08537.243
    (4.860)(5.236)(5.645)(5.169)
    Triglycerides1.1841.2131.2851.213
    (0.812)(0.814)(0.787)(0.809)
    Creatinine73.57278.63577.80076.057
    (13.397)(14.647)(14.853)(14.309)
    Panel D: Chronic Disease
    Cancer0.0460.0610.0880.059
    (0.209)(0.238)(0.284)(0.236)
    Stroke0.0070.0110.0120.009
    (0.084)(0.102)(0.109)(0.096)
    Heart attack0.0100.0140.0170.013
    (0.099)(0.118)(0.131)(0.112)
    Heart failure0.0070.0190.0240.014
    (0.083)(0.136)(0.154)(0.119)
    Diabetes0.0240.0360.0420.031
    (0.153)(0.186)(0.201)(0.175)
    Ulcerative colitis0.0060.0080.0100.007
    (0.076)(0.091)(0.098)(0.086)
    Gallstones0.0370.0460.0460.041
    (0.188)(0.208)(0.209)(0.199)
    Hepatitis0.0100.0110.0120.011
    (0.100)(0.105)(0.107)(0.103)
    Chronic fatigue0.0130.0160.0150.015
    (0.114)(0.127)(0.123)(0.120)
    Kidney stones0.0310.0380.0400.035
    (0.173)(0.191)(0.195)(0.184)
    Renal failure0.0000.0020.0020.001
    (0.000)(0.040)(0.046)(0.030)
    Arthritis0.0210.0330.0370.028
    (0.145)(0.178)(0.188)(0.165)
    Fibromyalgia0.0330.0420.0460.038
    (0.178)(0.201)(0.208)(0.192)
    Osteoarthritis0.0770.1590.1980.128
    (0.267)(0.365)(0.399)(0.334)
    Osteoporosis0.0150.0290.0340.023
    (0.122)(0.168)(0.180)(0.151)
    Repetitive strain injury0.0220.0350.0440.031
    (0.148)(0.183)(0.205)(0.173)
    Chronic obstructive pulmonary disease0.0530.0680.0670.061
    (0.224)(0.252)(0.249)(0.239)
    Dementia0.0000.0010.0010.001
    (0.011)(0.030)(0.032)(0.024)
    Parkinson’s0.0010.0010.0020.001
    (0.023)(0.037)(0.042)(0.033)
    • Notes: This table presents summary statistics by wave. For biomarkers, we report the mean of the original values, and for chronic diseases, we report the prevalence of specific conditions.

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    Table 5

    Regression Results of CDI and Three-Year Mortality on ALI and Lagged ALI

    Panel A: CDIPanel B: Three-Year Mortality
    (1)(2)(1)(2)
    ALI0.0642***0.0005***
    (0.0018)(0.0001)
    ALIa−t0.0714***0.0004***
    (0.0021)(0.0001)
    ControlsYesYesYesYes
    Observations120,083120,08392,36992,369
    R-squared0.1580.1580.0970.096
    • Notes: The analysis includes individuals who participated continuously in Lifelines for two waves, in order to obtain lagged health outcomes. The sample size in Panel B is reduced due to partly missing three-year mortality information in Lifelines wave 3a (see Section III.C for details). Panel A is estimated using a linear regression model, while Panel B employs a logistic regression model. Accordingly, we report average marginal effects for the latter. We present the R-squared for Panel A and the pseudo R-squared for Panel B. Robust standard errors are reported in parentheses. Control variables include age, age-squared, age group, gender, cohort, urban residency, province, and survey year. *p < 0.1, **p < 0.05, ***p < 0.01.

    • View popup
    Table 6

    Regression Results of CDI on ALI and Lagged ALI by Age Group

    25–3435–4445–54
    (1)(2)(1)(2)(1)(2)
    ALI0.0241***0.0508***0.0583***
    (0.0048)(0.0035)(0.0027)
    ALIa−t0.0316***0.0502***0.0712***
    (0.0051)(0.0038)(0.0033)
    ControlsYesYesYesYesYesYes
    Observations8,2878,28720,78920,78940,04640,046
    R-squared0.0200.0220.0360.0330.0360.039
    55–6465–74
    (1)(2)(1)(2)
    ALI0.0712***0.0751***
    (0.0037)(0.0059)
    ALIa−t0.0863***0.0723***
    (0.0041)(0.0064)
    ControlsYesYesYesYes
    Observations30,12030,12016,89816,898
    R-squared0.0510.0540.0380.037
    • Notes: The analysis includes individuals who participated continuously in Lifelines for two waves, in order to obtain lagged health outcomes. All regressions presented in Table 6 are estimated using linear regression models. Robust standard errors are shown in parentheses for all models. Control variables include age, age-squared, gender, cohort, urban residency, province, and survey year. *p < 0.1, **p < 0.05, ***p < 0.01.

    • View popup
    Table 7

    Regression Results of Three-Year Mortality on ALI and Lagged ALI by Age Group

    35–4445–54
    (1)(2)(1)(2)
    ALI0.0003***0.0005***
    (0.0001)(0.0002)
    ALIa−t0.0006***0.0006***
    (0.0002)(0.0002)
    ControlsYesYesYesYes
    Observations16,13616,13632,45832,458
    Pseudo R-squared0.0390.0940.0370.039
    55–6465–74
    (1)(2)(1)(2)
    ALI0.00030.0007
    (0.0003)(0.0007)
    ALIa−t0.0003−0.0003
    (0.0003)(0.0006)
    ControlsYesYesYesYes
    Observations20,34920,34911,90611,906
    Pseudo R-squared0.0140.0140.0230.022
    • Notes: The analysis includes individuals who participated continuously in Lifelines for two waves, in order to obtain lagged health outcomes. The sample size is smaller than in Tables 6, due to partial missing data on three-year mortality in Lifelines wave 3a (see Section III.C for details). All regressions in Tables 7 are estimated using logistic regression models. Accordingly, we report average marginal effects and pseudo R-squared values. Robust standard errors are reported in parentheses. Control variables include age, age-squared, gender, cohort, urban residency, province, and survey year. *p < 0.1, **p < 0.05, ***p < 0.01.

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Journal of Human Resources: 61 (Supplement)
Journal of Human Resources
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1 Jun 2026
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Lifetime Trajectories and Drivers of Socioeconomic Health Disparities
Ailun Shui, Gerard J. van den Berg, Jochen O. Mierau, Laura Viluma
Journal of Human Resources Jun 2026, 61 (Supplement) S98-S130; DOI: 10.3368/jhr.0225-14125R2

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Lifetime Trajectories and Drivers of Socioeconomic Health Disparities
Ailun Shui, Gerard J. van den Berg, Jochen O. Mierau, Laura Viluma
Journal of Human Resources Jun 2026, 61 (Supplement) S98-S130; DOI: 10.3368/jhr.0225-14125R2
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  • Article
    • Abstract
    • I. Introduction
    • II. Data
    • III. Allostatic Load, Chronic Disease, and Mortality
    • IV. Socioeconomic Health Disparities over the Life Cycle
    • V. Drivers of Allostatic Load over the Life Cycle
    • VI. Conclusions
    • Acknowledgments
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