The constant heavy chain (CH1) domain affects antibody affinity and fine specificity, challenging
the paradigm that only variable regions contribute to antigen binding. To investigate the …

The heparan sulfate proteoglycan agrin and adhesion molecules are key players in the
formation of neuronal and immune synapses that evolved for efficient communication at the sites …

Siglecs are transmembrane sialoglycan binding proteins, most of which are expressed on
leukocyte subsets and have inhibitory motifs that translate cell surface ligation into immune …

Background Balanced activation and inhibition of the immune system ensures pathogen
clearance while avoiding hyperinflammation. Siglecs, sialic acid–binding proteins found on …

Scope Our aim was to investigate whether dietary wolfberry altered carotenoid metabolic
gene expression and enhanced mitochondrial biogenesis in the retina of diabetic mice. …

Human siglecs are a family of 14 sialic acid-binding proteins, most of which are expressed
on subsets of immune cells where they regulate immune responses. Siglec-8 is expressed …

Vaccines are largely evaluated for their ability to promote adaptive immunity, with little focus
on the induction of negative immune regulators. Adjuvants facilitate and enhance vaccine-…

Mucosa, comprising epithelial and dendritic cells, are the major sites for Human Immunodeficiency
Virus type 1 (HIV-1) transmission. There, DCs can capture incoming HIV-1 and in turn …

There is significant interest in targeting MAIT cells with immunostimulatory agents to enhance
immune responses. Mycobacterium tuberculosis (M. tb.) is a pervasive respiratory disease …

Studying 5.6 million biomedical science articles published over three decades, we reconcile
conflicts in a long-standing interdisciplinary literature on scientists’ life-cycle productivity by …